Hi there.
Not a while ago, I've created a post about stsadm.exe / new SPSite() being slow in disconnected environments. Just wanted to point out that I've tried changing the setting on some other servers, and the results were most interesting. Almost every other MS product, starting from SQL Studio and ending in SCOM Console, loaded up faster, probably for being signed using AuthentiCode. So, if you have a disconnected server hosting some MS product, try changing this setting too! Remember it might reduce security when used with applications that actually can access their CRL listings, so if that's the case (You should know, since it would probably be an application developed in-house), use the MS application's .config file and not the machine.config one.
Happy boosting!